Serum uric acid levels in patients with different phenotypes of polycystic ovary syndrome

Key Points

• The research aims to compare serum uric acid levels among different phenotypes of polycystic ovary syndrome.
• Included 180 women with PCOS classified by phenotypes A, B, C, and D, plus 51 controls.
• Diagnosed PCOS using the 2003 Rotterdam criteria and assessed different phenotypes based on specific symptoms.
• Measured fasting serum uric acid using the uricase method, identifying hyperuricemia at levels ≥6.0 mg/dL.
• Conducted statistical analyses for normality and compared groups with parametric or non-parametric tests.
• Phenotype A showed significantly higher serum uric acid levels (4.8 mg/dL) than controls (4.1 mg/dL) and Phenotype C (4.2 mg/dL).
• Hyperuricemia was more frequent in PCOS subjects compared to controls, mainly in Phenotype A.
• Positive correlations were found between serum uric acid, body mass index (BMI), and waist circumference, though phenotypes did not significantly differ within BMI categories.