ABSTRACT Surgical antibiotic prophylaxis (SAP) is crucial in preventing postoperative surgical site infections (SSIs), especially in clean and clean‐contaminated surgeries. It was a prospective comparative observational study that compared the effectiveness and safety of single‐dose ceftriaxone monotherapy with amoxicillin–clavulanic acid as a combination therapy in preventing SSI. One hundred adult patients undergoing clean or clean‐contaminated operations were enrolled at a tertiary care hospital in India wherein 50 received ceftriaxone (1 g IV) and 50 received amoxicillin–clavulanic acid (1.2 g IV) preoperatively. The 30‐day follow‐up of the patients was conducted to determine the incidence of SSI, length of stay, and the adverse drug reactions (ADRs). The incidence of SSI was 8 percent among all patients, and the incidence in the ceftriaxone (6 percent) and amoxicillin–clavulanic acid (10 percent) arms did not differ significantly ( p > 0.05). No significant differences were found in mean hospital stay or ADR incidence and mild ADR was reported in only one instance. The two regimens proved equally effective and safe in SAP, and single‐dose ceftriaxone was found to be a potentially effective and convenient alternative for SSI prevention but further randomized trials are warranted.
Ullah et al. (Fri,) studied this question.
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