Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study
In vitro study compares remineralization of initial caries in dentifrice with hydroxyapatite and fluoride, suggesting similar effectiveness.
Key Points
This research aims to compare the caries remineralizing effects of different dentifrices containing natural hydroxyapatite, synthetic hydroxyapatite, and fluoride.
Created initial carious lesions on bovine enamel blocks via demineralization.
Applied seven different treatments, including various formulations of natural and synthetic hydroxyapatite and fluoride toothpaste.
Conducted 28-day remineralization using a pH cycling model with daily treatment regimens and acidic challenges.
Measured surface microhardness before and after remineralization.
Performed statistical analyses to compare results among groups.
All treatment groups showed significant remineralization of carious lesions (p < 0.001).
The remineralization percentage was significantly lower for artificial saliva (9.61%) compared to 30% natural hydroxyapatite (29.21%) and fluoride (27.05%).
No significant differences in remineralization percentage were found among natural hydroxyapatite formulations or between natural and synthetic hydroxyapatite.