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February 5, 2026Dentistry JournalOpen Access

Enamel Remineralization Potential of Conventional and Biomimetic Toothpaste Formulations: A Comparative In Vitro Study

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Authors

CGCristina-Angela GhiorgheITIonuţ TărăboanţăSASorin Andrian

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Overview

In vitro study compares fluoride and biomimetic toothpastes’ effects on enamel remineralization, suggesting varying efficacies.

Key Points

  • The aim was to evaluate and compare the enamel remineralization efficacy of various therapeutic toothpaste formulations.
  • Prepared 60 enamel specimens from human teeth and artificially demineralized them.
  • Allocated samples into six groups for a 28-day remineralization treatment protocol.
  • Applied scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) to analyze mineral content and surface morphology.
  • Conducted Vickers microhardness testing to assess mechanical properties of enamel.
  • Performed statistical analyses including ANOVA and post hoc tests.
  • All toothpaste formulations increased mineral content compared to the control.
  • Significant increases in calcium, phosphorus, and fluoride levels were noted in specific groups at day 28 (p < 0.001).
  • Arginine-fluoride and NovaMin formulations showed the highest increases in mineral content.
  • Nano-hydroxyapatite/xylitol showed gradual remineralization effects, while CPP-ACP demonstrated limited changes.
  • Higher Vickers microhardness values correlated with greater mineral levels in several toothpaste groups (p < 0.05).

Cite This Study

Ghiorghe et al. (2026) studied this question.

synapsesocial.com/papers/698435d5f1d9ada3c1fb50dehttps://doi.org/10.3390/dj14020082
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