What question did this study set out to answer?

The aim is to compare the remineralization efficacy of nano-hydroxyapatite with fluoride against other formulations for enamel repair.

August 9, 2026BMC Oral HealthOpen Access

Enhanced enamel remineralization by a nanohydroxyapatite-fluoride biomimetic formulation: a comparative in vitro study

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In vitro study compares remineralization efficacy of biomimetic formulations on enamel lesions, revealing significant differences.

The aim is to compare the remineralization efficacy of nano-hydroxyapatite with fluoride against other formulations for enamel repair.
Created artificial enamel lesions on 64 human enamel specimens using a pH-cycling model.
Assigned specimens to four groups for remineralization treatment and measured surface microhardness (SMH) with Vickers test.
Conducted statistical analysis using two-way ANOVA and Tukey’s post hoc tests.
The nHAP + NaF group reached the highest SMHR% of 62.76% (p < 0.001).
CPP-ACP and BioC groups showed lower SMHR% of 52.21% and 42.17%, respectively.
Control group had the lowest recovery at 14.11% (p < 0.001).

Muhçi et al. (2026) studied this question.

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