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February 5, 2026Psychological Medicine

A stage-specific cascade of neural dysfunction emotional conflict processing in major depressive disorder

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Authors

DLDong LiDLDan LiRLRui Liu

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Overview

Reveals neural dysfunction in emotional conflict processing in major depressive disorder, indicating critical stages for intervention.

Key Points

  • This research aims to clarify neural dynamics involved in emotional conflict processing in major depressive disorder (MDD).
  • Used high-temporal-resolution EEG to investigate emotional processing stages.
  • Recruited 175 medication-free MDD patients and 101 healthy controls for emotional Stroop task.
  • Analyzed event-related potentials (N250, N450, LSP) with ANOVA to assess group differences.
  • MDD group showed hypoactivation in initial conflict monitoring (N250 amplitude).
  • MDD demonstrated compensatory hyperactivation in conflict inhibition (N450 interaction).
  • Lowered LSP amplitude in MDD indicated hypoactivation during conflict resolution for negative stimuli.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb07bahttps://doi.org/10.1017/s0033291726103171
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