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May 30, 2026Frontiers in Psychiatry0 citationsOpen Access

Task-State P300 and Functional Brain Network Abnormalities in Adolescent Major Depressive Disorder

Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study

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Authors

YKYanna KouJLJuan LiYSYajing Si

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Overview

Randomized trial investigates P300 and brain connectivity differences in adolescents with major depressive disorder, suggesting EEG biomarkers for diagnosis.

Key Points

  • This study aims to explore the neurophysiological mechanisms underpinning cognitive control deficits in adolescent major depressive disorder.
  • 22 adolescents with major depressive disorder and 15 healthy controls performed a Stroop task during 32-channel EEG recording.
  • P300 amplitude and latency, power spectral density, and functional connectivity were analyzed using phase locking value.
  • A support vector machine classifier assessed diagnostic utility with leave-one-out cross-validation.
  • MDD participants showed prolonged reaction times and reduced P300 amplitude (Oz, PO7, O2).
  • Enhanced alpha/beta-band power spectral density in occipitotemporal regions was observed in the MDD group.
  • The SVM model achieved 86.49% classification accuracy for distinguishing MDD from healthy controls.

Cite This Study

Kou et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e2f0307b78509430f3ahttps://doi.org/10.3389/fpsyt.2026.1778443
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