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July 31, 2026BMC PsychiatryOpen Access

Neural mechanisms of cognitive dysfunction in depression: dual-task event-related potentials and task-phase-dependent EEG functional connectivity

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Authors

YZYongxiang ZhangJLJing LiHZHuifei Zhang

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Overview

Randomized trial explores cognitive dysfunction mechanisms in depression, suggesting significant neurophysiological evidence.

Key Points

  • This research aims to uncover the neurophysiological characteristics linked to cognitive dysfunction in depression.
  • 30 patients with depression and 30 healthy controls underwent EEG recordings during various tasks.
  • Electrophysiological measures included N170 and N270 event-related potentials and functional connectivity analysis.
  • Data corrections were made using the Benjamini–Hochberg false discovery rate.
  • The depression group showed longer N170 and N270 latencies (p-values not specified) and altered amplitudes when compared to controls.
  • Longer N170 and N270 latencies correlated with more severe depressive symptoms in the depression group.
  • Task-phase-dependent brain network imbalances were identified, showing no significant ties to clinical variables.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a6c46c0747664a1aa73ba95https://doi.org/10.1186/s12888-026-08436-9
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