Why the study?
Depression is associated with impaired decision-making and resting frontal brain asymmetry, but brain asymmetry during decision-making under negative and positive feedback conditions remained to be investigated.
Does brain asymmetry differ between patients with Major Depressive Disorder and healthy controls during a decision-making task?
Population
60 MDD patients and 60 healthy participants
Comparison
MDD patients vs healthy control participants during a multi-stage decision-making task
Design
Case-control study
Key result
Major Depressive Disorder was characterized by a lack of left dominance during the resting state and left hypoactivity during the task baseline and subsequent decision-making process.
Authors
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Brain asymmetry during MDD decision-making feedback needs replication; leaves open valence-specific lateralization markers for targeted interventions.
Case-Control (n=120)
Does brain asymmetry differ between patients with Major Depressive Disorder and healthy controls during a decision-making task?
MDD is associated with altered brain asymmetry, specifically left hypoactivity, during decision-making tasks, highlighting potential EEG biomarkers for depression.
Kustubayeva et al. (2020) conducted a case-control in Major Depressive Disorder (n=120). Major Depressive Disorder vs. Healthy controls was evaluated on Brain asymmetry (alpha power and ERP amplitudes) during a decision-making task. Major Depressive Disorder was characterized by a lack of left dominance during the resting state and left hypoactivity during the task baseline and subsequent decision-making process.
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