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February 5, 2026Neural Regeneration ResearchOpen Access

Metabolic reprogramming of microglia: Effects on development, disease, and therapeutic potential

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Authors

HZHaiwei ZhangFlorida International UniversityMJMengmeng JinRutgers, The State University of New JerseyPJPeng JiangRutgers, The State University of New Jersey

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Implication

This review uncovers how metabolic reprogramming affects microglial function in the central nervous system, suggesting new therapeutic approaches.

Key Points

  • The aim is to explore the metabolic mechanisms that influence microglial function and their implications for disease and therapy.
  • Reviewed existing literature on microglial metabolism, development, and disease.
  • Analyzed metabolic plasticity and region-specific adaptations of microglia.
  • Integrated molecular, transcriptomic, and metabolomic data to understand microglial responses.
  • Demonstrated a link between metabolic state and microglial activation.
  • Found that lipid metabolism and energy utilization play crucial roles in immune regulation.
  • Highlighted potential therapeutic strategies targeting microglial metabolic pathways in neurodegenerative diseases.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb0834https://doi.org/10.4103/nrr.nrr-d-25-01298
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glucose metabolic reprogramming: mechanisms and therapeutic implications in neuroinflammation2026 · 1 citations
  2. 2“Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders”2025 · 55 citations
  3. 3“Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders”2025
  4. 4Metabolic Reprogramming of Microglia in Neuroinflammation and Depression2026 · 1 citations
  5. 5Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain2025 · 11 citations