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This review examines the role of glucose metabolic reprogramming in microglial function and neuroinflammation.

June 20, 2026Frontiers in ImmunologyOpen Access

Glucose metabolic reprogramming: mechanisms and therapeutic implications in neuroinflammation

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Review reveals metabolic changes in microglia during neuroinflammation, suggesting new therapies for neurodegenerative diseases.

This review examines the role of glucose metabolic reprogramming in microglial function and neuroinflammation.
Discussed the glucose-glycolysis-lactate metabolic axis in microglial immunometabolism.
Analyzed key glycolytic enzymes and metabolites regulating microglial functions.
Explored therapeutic strategies targeting glycolytic shifts to reduce neuroinflammation.
Identified that microglia shift to enhanced aerobic glycolysis during neuroinflammation.
Highlighted the role of HK2 and PKM2 in regulating microglial function.
Proposed novel therapeutic approaches based on glycolytic reprogramming to tackle neurodegenerative diseases.

Zhang et al. (2026) studied this question.

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