PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
February 5, 2026MedicineOpen Access

Development and validation of a predictive model for post-endoscopic retrograde cholangiopancreatography cholangitis: A risk factors based nomogram

View Full Paper
Ask AI
Bookmark
Share

Authors

WZWenjie ZhangAWAnqi WeiGXGuanghua Xie

Discussion

Loading...

Member takes

Overview

Validation of a risk factors-based nomogram predicts cholangitis post-ERCP, suggesting enhanced clinical decision-making.

Key Points

  • This research aims to identify key risk factors for post-ERC cholangitis and develop a predictive model to enhance risk assessment.
  • Cohort randomly divided into training and validation sets at a 7:3 ratio.
  • Screened risk factors using univariate analysis, LASSO regression, and multivariate logistic regression.
  • Developed a nomogram based on independent risk factors identified from analyses.
  • Assessed model performance using receiver operating characteristic curves and calibration curves.
  • Evaluated clinical utility through decision curve analysis and clinical impact curve.
  • Identified significant risk factors including diabetes mellitus, previous ERCP, malignant biliary obstruction, high biliary obstruction, and low albumin levels.
  • Achieved an area under the curve of 0.903 in the training set and 0.884 in the validation set.
  • Calibration curve demonstrated strong alignment between predictions and actual outcomes.
  • No significant deviation observed in predicted vs. actual values per the H–L test results.
  • Model showed significant net clinical benefit across various risk thresholds.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/698433a5f1d9ada3c1fb103dhttps://doi.org/10.1097/md.0000000000047519
View Full Paper
Ask AI
Bookmark
Share