Key result
Higher BMI in patients with coronary artery disease was associated with poorer control of medical risk factors (OR 1.06; 95% CI 1.03-1.10; p<0.001) and a greater burden of comorbidities.
Why the study?
Optimal body weight and target control are essential in secondary prevention following acute coronary events, prompting evaluation of treatment strategies and lifestyle modifications in patients with obesity during long-term follow-up.
Observational (n=788)
Yes
Effect estimate: OR 1.06 (95% CI 1.03-1.10)
p-value: p=<0.001
In patients 6-18 months post-ACS or revascularization, higher BMI is associated with poorer control of medical risk factors but better control of lifestyle-related risk factors, highlighting the need for personalized secondary prevention.
Background: Obesity substantially increases cardiovascular risk and contributes to the accumulation of cardiometabolic risk factors. Achieving optimal control of body weight and guideline-recommended targets is essential in high-risk patients, particularly in secondary prevention following acute coronary events. This study aimed to evaluate treatment strategies and lifestyle modifications undertaken by patients with obesity during long-term follow-up. Methods: This analysis included patients enrolled 6–18 months after acute coronary syndrome or coronary revascularization within the multicentre POLASPIRE II study. Standardized EUROASPIRE methodology was applied to collect clinical, anthropometric, and lifestyle-related data. Results: A total of 788 patients (mean age 65.4 ± 8.9 years; 25.8% women) were included, of whom 40.6% had obesity. No significant association between sex and BMI was observed (β = −0.48; 95% CI −1.30 to 0.31; p = 0.20). Increasing age was associated with lower BMI (β = −0.05; 95% CI −0.09 to −0.0001; p = 0.044), and higher education correlated with lower BMI (β = −1.10; 95% CI −2.00 to −0.22; p = 0.015). With advancing age (OR 1.02; 95% CI 1.002–1.033; p = 0.023) and increasing BMI (OR 1.11; 95% CI 1.076–1.138; p = 0.001), the number of risk factors and comorbidities increased. Higher BMI was associated with poorer control of medical risk factors (OR 1.06; 95% CI 1.03–1.10; p < 0.001), whereas patients with higher BMI demonstrated better control of lifestyle-related risk factors (OR 0.95; 95% CI 0.919–0.983; p = 0.003). Conclusions: Obesity is highly prevalent among high-risk cardiovascular patients and is associated with a greater burden of comorbidities and poorer control of medical risk factors. These findings support the need for strengthened, risk-stratified secondary prevention strategies and more personalized therapeutic approaches in patients with obesity.
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Kosior et al. (2026) conducted an observational in Coronary Artery Disease (n=788). Higher BMI / Obesity was evaluated on Poorer control of medical risk factors (OR 1.06, 95% CI 1.03-1.10, p=<0.001). Higher BMI in patients with coronary artery disease was associated with poorer control of medical risk factors (OR 1.06; 95% CI 1.03-1.10; p<0.001) and a greater burden of comorbidities.
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