February 1, 2002Obesity Research
Obesity and Long‐Term Clinical and Economic Outcomes in Coronary Artery Disease Patients
Key result
Increased BMI in 9,405 ACS patients was associated with more clinical events and higher inpatient costs over 10 years, but not with differences in adjusted 10-year survival.
Why the study?
Does increasing BMI worsen 10-year clinical and economic outcomes in patients with acute coronary syndrome?
Population
9,405 acute coronary syndrome patients with significant CAD receiving an initial cardiac catheterization at…
Comparison
Increasing body mass index categories vs Normal BMI
Design
Cohort
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Obese ACS patients incur greater event burden and costs; leaves open whether BMI modification improves survival.
Study Design
Type
Cohort (n=9,405)
Multicenter
No
Structured PICO
Does increasing BMI worsen 10-year clinical and economic outcomes in patients with acute coronary syndrome?
P
Population
9,405 acute coronary syndrome (ACS) patients with significant CAD receiving an initial cardiac catheterization at Duke University Medical Center between 1986 and 1997. Excluded: BMI < 18.5 kg/m2.
I
Intervention
Increasing body mass index (BMI) categories (overweight, obese, very obese)
C
Comparator
Normal BMI
O
Outcome
10-year clinical events, cumulative inpatient medical costs, and survivalhard clinical
Obese ACS patients incur higher inpatient costs and more clinical events over 10 years, highlighting the need for aggressive weight management and secondary prevention, despite similar adjusted 10-year survival compared to non-obese patients.
Cite This Study
Eisenstein et al. (2002) conducted a cohort in Acute coronary syndrome (ACS) with significant CAD (n=9,405). Obesity / Increased BMI vs. Normal BMI / Non-obese was evaluated on 10-year clinical events, cumulative inpatient medical costs, and survival. Increased BMI in 9,405 ACS patients was associated with more clinical events and higher inpatient costs over 10 years, but not with differences in adjusted 10-year survival.