Key result
Obesity (BMI ≥30 kg/m2) was associated with earlier development of coronary artery disease compared to non-obese patients (mean age 57 vs 63.3 years; p<0.001).
Why the study?
Does a BMI ≥30 kg/m2 correlate with earlier onset and specific patterns of coronary artery disease in patients undergoing cardiac catheterization for chest pain?
Observational (n=7,567)
Does a BMI ≥30 kg/m2 correlate with earlier onset and specific patterns of coronary artery disease in patients undergoing cardiac catheterization for chest pain?
Absolute Event Rate: 57% vs 63.3%
p-value: p=<0.001
Obesity (BMI ≥30 kg/m2) is associated with an earlier onset of coronary artery disease, with male gender and smoking being major drivers for obstructive CAD in this population.
Obesity was associated with earlier CAD onset; extends prior observations but leaves open whether weight reduction alters trajectory.
OBJECTIVE: In this study, we evaluated obesity as a single risk factor for coronary artery disease (CAD), along with the synergistic effect of obesity and other risk factors. METHODS: A retrospective study of 7,567 patients admitted to hospital for chest pain from 2005 to 2014 and underwent cardiac catheterization. Patients were divided into two groups: obese and normal with body mass index (BMI) calculated as ≥30 kg/m(2) and <25, respectively. We assessed the modifiable and non-modifiable risk factors in obese patients and the degree of CAD. RESULTS: Of the 7,567 patients who underwent cardiac catheterization, 414 (5.5%) had a BMI ≥30. Of 414 obese patients, 332 (80%) had evidence of CAD. Obese patients displayed evidence of CAD at the age of 57 versus 63.3 in non-obese patients (p<0.001). Of the 332 patients with CAD and obesity, 55.4% had obstructive CAD versus 44.6% with non-obstructive CAD. In obese patients with CAD, male gender and history of smoking were major risk factors for development of obstructive CAD (p=0.001 and 0.01, respectively) while dyslipidemia was a major risk factor for non-obstructive CAD (p=0.01). Additionally, obese patients with more than one risk factor developed obstructive CAD compared to non-obstructive CAD (p=0.003). CONCLUSION: Having a BMI ≥30 appears to be a risk factor for early development of CAD. Severity of CAD in obese patients is depicted on non-modifiable and modifiable risk factors such as the male gender and smoking or greater than one risk factor, respectively.
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Alkhawam et al. (2016) conducted an observational in Coronary artery disease (n=7,567). Obesity (BMI ≥30 kg/m2) vs. Normal BMI (<25 kg/m2) was evaluated on Age at evidence of coronary artery disease (p=<0.001). Obesity (BMI ≥30 kg/m2) was associated with earlier development of coronary artery disease compared to non-obese patients (mean age 57 vs 63.3 years; p<0.001).
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