Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13 874 patients
Why the study?
Does higher BMI increase the prevalence and severity of CAD and the risk of myocardial infarction in patients without known CAD undergoing CCTA?
Population
13,874 patients without known coronary artery disease referred for coronary computed tomographic angiography…
Comparison
Higher body mass index, categorized as… vs Lower BMI categories (e.g., normal weight).
Design
Cohort
Follow-up
mean 2.4 ± 1.2 years
Authors
Discussion
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Member takes
Implication
Higher BMI signals elevated MI risk during CCTA follow-up; extends prior associations but leaves causal effects and intervention benefits open.
Structured PICO
Does higher BMI increase the prevalence and severity of CAD and the risk of myocardial infarction in patients without known CAD undergoing CCTA?
P
Population
13,874 patients without known coronary artery disease (CAD) referred for coronary computed tomographic angiography (CCTA) from a prospective, international, multicentre registry.
I
Intervention
Higher body mass index (BMI), categorized as underweight (18.5-20.0 kg/m²), normal (20.1-24.9 kg/m²), overweight (25-29.9 kg/m²), and obese (≥30 kg/m²).
C
Comparator
Lower BMI categories (e.g., normal weight).
O
Outcome
Presence, extent, and severity of CAD on CCTA, and risk of all-cause mortality and non-fatal myocardial infarction (MI).hard clinical
In patients without known CAD undergoing CCTA, higher BMI is independently associated with a greater prevalence and severity of CAD, as well as an increased intermediate-term risk of myocardial infarction.
Cite This Study
LaBounty et al. (2012) studied this question.