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February 5, 2026Chemical ScienceOpen Access

Allosteric ligand–aptamer complexes orchestrate supramolecular or transient catalytic, transcription and fibrinogenesis processes

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Authors

DFDiva FroimHAHadar AmartelyJDJiantong Dong

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Overview

This investigation demonstrates the role of ligand-aptamer complexes in regulating transcription and fibrinogenesis, indicating new pathways for therapeutic development.

Key Points

  • The aim is to explore how ligand-aptamer interactions enhance the function of DNAzymes and transcription machinery.
  • Investigation of allosteric stabilization of DNAzyme and anti-thrombin aptamer.
  • Characterization of molecular complexes involving aptamers and catalytic subunits.
  • Analysis of transcription processes influenced by ligand-aptamer interactions.
  • Ligand/aptamer complexes significantly stabilize the DNAzyme function.
  • Enhanced transcriptional activity observed in conditions with allosteric stabilization.
  • Increased efficiency in fibrinogenesis processes linked to aptamer-ligand interactions.

Cite This Study

Froim et al. (2026) studied this question.

synapsesocial.com/papers/698434b4f1d9ada3c1fb31bchttps://doi.org/10.1039/d5sc09098a
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Also Consider

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  1. 1Aptamer‐Based DNA Allosteric Switch for Regulation of Protein Activity2024 · 14 citations
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  3. 3A Nucleotide‐Derived Fluorophore for Visualizing G‐Quadruplex Assembly and Introduction of Cation‐Regulated Activity into the Thrombin Binding Aptamer2025
  4. 4G-Quadruplex Structure in the ATP-Binding DNA Aptamer Strongly Modulates Ligand Binding Activity2024 · 5 citations
  5. 5Programming Aptamer–Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure2025 · 8 citations