Observational findings reveal that lower physical activity complexity is linked to poorer cognition in older adults, suggesting its potential as an early indicator of Alzheimer's disease.
Key Points
This research aims to investigate the relationship between physical activity complexity, cognitive function, and plasma biomarkers of Alzheimer's disease.
Developed a physical activity complexity measure using multiscale entropy
Analyzed data from 164 older adults using wrist-worn accelerometers and neuropsychological tests
Measured plasma biomarkers including Aβ42, Aβ40, and various p-tau forms
Participants with cognitive decline had lower physical activity complexity than cognitively unimpaired individuals
Poor cognitive function was significantly associated with lower physical activity complexity (p < 0.03)
Greater day-to-day variability in physical activity complexity correlated with higher plasma p-tau levels