A synbiotic consisting of Lactiplantibacillus plantarum S58 and β-glucan ameliorate exertional heat stroke-induced intestinal barrier injury via modulating MAPK pathway and gut microbiota in rats.

Juelin Chen; Jiawei Zhou; Jianyao You; Yawei Wang; Yankun Pei; Yitong Gong; Yangyang Cao; Muge Song; haoran Sun; Meng Wang; Weiyi Ma; Jun Ma; Qing Song; Ji-Kuai Chen; Wenjun Chang; Jiajia Song; Huayi Suo; Guanyu Yu; Lei Li; Shuogui Xu

doi:10.1039/d5fo05285h

January 1, 2026Food & Function

A synbiotic consisting of Lactiplantibacillus plantarum S58 and β-glucan ameliorate exertional heat stroke-induced intestinal barrier injury via modulating MAPK pathway and gut microbiota in rats.

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Key Points

This research aims to investigate the effects of a synbiotic consisting of Lactiplantibacillus plantarum S58 and β-glucan on intestinal barrier injury caused by exertional heat stroke.
Utilized a rat model to simulate exertional heat stroke conditions.
Administered a synbiotic treatment comprising Lactiplantibacillus plantarum S58 and β-glucan.
Assessed the impact on intestinal barrier function and gut microbiota composition.
Analyzed signaling pathways, specifically the MAPK pathway, involved in response to injury.
The synbiotic treatment significantly improved intestinal barrier integrity in heat-stressed rats.
Alterations in gut microbiota composition were observed following treatment, indicating positive modulation.
MAPK pathway activity was effectively regulated, contributing to the protective effects of the treatment.

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Implication

Research demonstrates that a synbiotic improves intestinal barrier injury in rats with exertional heat stroke, suggesting therapeutic potential for EHS.

Abstract

Exertional heat stroke (EHS) is a severe and potentially life-threatening condition that primarily affects healthy individuals engaged in strenuous physical activity under hot and humid environments, representing an escalating public...

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Chen et al. (2026) studied this question.

synapsesocial.com/papers/698435f0f1d9ada3c1fb563c https://doi.org/10.1039/d5fo05285h

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A synbiotic consisting of Lactiplantibacillus plantarum S58 and β-glucan ameliorate exertional heat stroke-induced intestinal barrier injury via modulating MAPK pathway and gut microbiota in rats.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A synbiotic consisting of Lactiplantibacillus plantarum S58 and β-glucan ameliorate exertional heat stroke-induced intestinal barrier injury via modulating MAPK pathway and gut microbiota in rats.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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