Direct NF₂ Functionalization of Ketones: A Mild Strategy for Accessing High-Performance gem-Difluoroamino Compounds

Yuehui Wang; Lele Wen; Lin Ling; Chun-Hui Xing; Long Lv

doi:10.1039/d6cc00009f

January 1, 2026Chemical Communications

Direct NF₂ Functionalization of Ketones: A Mild Strategy for Accessing High-Performance gem-Difluoroamino Compounds

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Key Points

This research aims to develop a mild strategy for functionalizing ketones to create gem-difluoroamino compounds.
Utilized Me4NSO3NF2 as a reagent
Focused on the conversion of aromatic ketones
Characterized resulting compounds using structural confirmation techniques.
Successfully obtained novel gem-difluoroamino compounds
Demonstrated efficient transformation under mild conditions
Confirmed the structures of the synthesized compounds.

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Implication

A method converts aromatic ketones into gem-difluoramino compounds, implying broader synthetic possibilities.

Abstract

The difluoroamino (NF2) group is a highly valuable energetic moiety. This work presents a mild method for converting aromatic ketones into novel gem-difluoramino compounds using Me4NSO3NF2. Their structures were confirmed...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6984360af1d9ada3c1fb58c9 https://doi.org/10.1039/d6cc00009f

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Direct NF₂ Functionalization of Ketones: A Mild Strategy for Accessing High-Performance gem-Difluoroamino Compounds

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Direct NF₂ Functionalization of Ketones: A Mild Strategy for Accessing High-Performance gem-Difluoroamino Compounds

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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