Peripheral Chemoreflex and Baroreflex Interactions in Cardiovascular Regulation in Humans
Key result
Isocapnic hypoxia increased heart rate by 20.8% (from 61.9 to 74.7 beats/min) and mean arterial pressure by 6.6% (from 97.4 to 103.9 mmHg) without altering baroreflex sensitivity.
Why the study?
Does acute isocapnic hypoxia alter baroreflex control of heart rate and sympathetic activity in healthy subjects?
Population
Healthy, non-smoking, normotensive subjects (19-36 years)
Comparison
Acute isocapnic hypoxia vs Normoxia and isocapnic hyperpnoea
Design
Other
Authors
Discussion
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Member takes
Implication
Highlights chemoreflex effects on autonomic control in animals; leaves open human translation and clinical relevance.
Structured PICO
Does acute isocapnic hypoxia alter baroreflex control of heart rate and sympathetic activity in healthy subjects?
P
Population
Healthy, non-smoking, normotensive subjects (19-36 years)
I
Intervention
Acute isocapnic hypoxia (85% arterial O2 saturation)
C
Comparator
Normoxia and isocapnic hyperpnoea
O
Outcome
Baroreflex control of heart rate and muscle sympathetic nerve activitysurrogate
Acute activation of peripheral chemoreceptors with isocapnic hypoxia resets baroreflex control of heart rate and sympathetic activity to higher pressures without changing baroreflex sensitivity.
Cite This Study
Halliwill et al. (2003) studied this question. Isocapnic hypoxia increased heart rate by 20.8% (from 61.9 to 74.7 beats/min) and mean arterial pressure by 6.6% (from 97.4 to 103.9 mmHg) without altering baroreflex sensitivity.