Palmitic acid aggravates atopic dermatitis by regulating SGK1/NEDD4L-involved cutaneous neuroimmune inflammation through driving TRPV1 and MRGPRB2 S-palmitoylation

Key Points

• The study investigates how palmitic acid contributes to inflammation in atopic dermatitis via specific molecular pathways.
• Analyzed the effects of palmitic acid on TRPV1 and MRGPRB2 S-palmitoylation in nociceptors and mast cells.
• Examined the role of SGK1 and NEDD4L phosphorylation status in mediating inflammation.
• Monitored production of substance P and tryptase release in response to S-palmitoylation changes.
• Palmitic acid increased TRPV1 S-palmitoylation, enhancing pain signaling in nociceptors.
• Found that NEDD4L phosphorylation status affected MRGPRB2 S-palmitoylation and tryptase release.
• Identified a potential mechanism linking palmitic acid to worsening atopic dermatitis symptoms.