Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis

Ioana Nicorescu; Amanda Thomson; George Merces; Jack Harrison; Ben Millar; Arthur G. Pratt; Amy E. Anderson; Julie Diboll; Kenneth S. Rankin; Domenico Somma; Mariola Kurowska-Stolarska; Luke J. Jones; Andrew Filer; David McDonald; Andrew Filby; John D. Isaacs; Catharien M.U. Hilkens

doi:10.1016/j.ard.2026.01.004

February 1, 2026Annals of the Rheumatic DiseasesOpen Access

Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis

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Key Points

The research aims to explore how autologous tolerogenic dendritic cells affect the immune environment in rheumatoid and inflammatory arthritis.
Conducted intra-articular injections of autologous tolerogenic dendritic cells in affected joints.
Examined changes in the synovial immune landscape post-treatment.
Analyzed the increase in synovial Myeloid MerTK<sup>High</sup> cells.
Observed a significant increase in Myeloid MerTK<sup>High</sup> cells in the synovial tissue after treatment.
Demonstrated potential local immune modulatory effects from the tolDC therapy.

Implication

This investigation reveals immune modulation in rheumatoid and inflammatory arthritis via tolDC treatment, suggesting potential therapeutic benefits.

Abstract

The tolDC-induced increase in synovial Myeloid MerTKHigh cells may have local immune modulatory effects and provide promising evidence for an effect of tolDC treatment on the synovial immune landscape.

Discussion

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Cite This Study

Nicorescu et al. (2026) studied this question.

synapsesocial.com/papers/698584b78f7c464f230081ab https://doi.org/10.1016/j.ard.2026.01.004

View Full Paper

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Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis

Key Points

Implication

Abstract

Discussion

Cite This Study

Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis

Key Points

Implication

Abstract

Discussion

Cite This Study

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