Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis | Synapse
February 6, 2026Annals of the Rheumatic Diseases0 citationsOpen Access
The research aims to explore how autologous tolerogenic dendritic cells affect the immune environment in rheumatoid and inflammatory arthritis.
Conducted intra-articular injections of autologous tolerogenic dendritic cells in affected joints.
Examined changes in the synovial immune landscape post-treatment.
Analyzed the increase in synovial Myeloid MerTK<sup>High</sup> cells.
Observed a significant increase in Myeloid MerTK<sup>High</sup> cells in the synovial tissue after treatment.
Demonstrated potential local immune modulatory effects from the tolDC therapy.
Abstract
The tolDC-induced increase in synovial Myeloid MerTKHigh cells may have local immune modulatory effects and provide promising evidence for an effect of tolDC treatment on the synovial immune landscape.