What question did this study set out to answer?

The study aims to investigate the protective effects of CMPF on erectile dysfunction and metabolic dysfunction.

February 6, 2026The Aging Male0 citationsOpen Access

The role of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in erectile dysfunction: an integrated mendelian randomization, network pharmacology, and multi-omics study

YLYugen LiNorth Sichuan Medical University GZGuangqiang ZhuNorth Sichuan Medical University CTChunlin TanNorth Sichuan Medical University

Key Points

The study aims to investigate the protective effects of CMPF on erectile dysfunction and metabolic dysfunction.
Employs Mendelian randomization
Uses network pharmacology techniques
Applies multi-omics approaches to identify regulators
Analyzes key molecular pathways involved
CMPF shows significant protective effects against erectile dysfunction
Identifies LGALS3, DPP4, and NR3C2 as crucial regulators
Supports CMPF's role as a bioactive compound from diet
Suggests nutritional interventions for managing erectile dysfunction

Abstract

CMPF exerts protective effects against ED and metabolic dysfunction through multi-target modulation, with LGALS3, DPP4, and NR3C2 as central regulators. These findings support CMPF as a diet-derived bioactive metabolite with potential for nutritional interventions and multi-target therapeutic strategies in ED.

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