Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti- Mycobacterium tuberculosis agents

Key Points

• The research aims to design and synthesize new compounds that inhibit InhA to provide potential treatments for multidrug-resistant tuberculosis.
• Design of thiazolopyridine compounds
• Synthesis of inhibitors
• Molecular modeling of compound interactions with InhA
• Identified novel thiazolopyridine-based inhibitors
• Demonstrated effectiveness in inhibiting InhA
• Potentially viable options for treating MDR-TB