Patients with HFpEF were older (73.2 vs. 70.4 years; p<0.001) and had more frequent hypertension (85.4% vs. 71.5%) and atrial fibrillation (52% vs. 44.7%) compared to those with HFrEF.
Observational (n=2,178)
Yes
HFrEF and HFpEF present with distinct clinical profiles, with HFpEF patients being older, more often female, and having higher rates of hypertension and atrial fibrillation, whereas HFrEF patients are more often male with a history of ischemic heart disease and higher natriuretic peptide levels.
Abstract Introduction Globally, heart failure is recognized as one of the most widespread cardiovascular disorders, characterized by high morbidity and mortality rates, as well as significant socioeconomic impact. The aim of our study was to define the characteristics and differences among patients with heart failure with preserved ejection fraction (HFpEF) and those with reduced ejection fraction (HFrEF). Materials and Methods The research was conducted as a clinical, retrospective, multicenter study, including participants from four medical centers in Serbia. Patients were divided into two groups – HFrEF (EF 50%) and HFpEF (EF ≥50%). Data on patients were collected from medical records, including basic anthropometric characteristics, comorbidities, echocardiographic and laboratory parameters, as well as clinical presentation data. Results The analysis included 2178 patients, of whom 73.2% had HFrEF and 26.8% had HFpEF. Compared to patients with HFrEF, HFpEF patients were older (73.2 vs. 70.4 years; p0.001), had a higher body mass index (29.0 vs. 27.7 kg/m²; p0.001), while patients with HFrEF were more often male (69.2% vs. 45.6%; p0.001), had more frequent myocardial infarction history (42.3% vs. 28.7%; p0.001), and underwent invasive procedures for the treatment of ischemic heart disease (30.2% vs. 19%; p0.001). Among HFpEF patients, there was more frequent presence of arterial hypertension (85.4% vs. 71.5%; p0.001) and atrial fibrillation (52% vs. 44.7%; p0.005). In terms of clinical presentation and symptoms, HFpEF patients more commonly experienced fatigue, leg swelling, and palpitations (p0.001). Analyzing echocardiographic and laboratory parameters, HFrEF patients had significantly higher values of LVIDd, LVIDs, LVEDV, and LA (p0.001), as well as natriuretic peptide levels (7173.09 pg/mL vs. 2012 pg/mL; p0.001). Conclusion Identifying the characteristics and differences between HFrEF and HFpEF patients contributes to a more thorough and comprehensive approach to treatment, as well as the formation of targeted therapeutic strategies in heart failure management.
Preveden et al. (Sat,) conducted a observational in Heart failure (n=2,178). Heart failure with preserved ejection fraction (HFpEF) vs. Heart failure with reduced ejection fraction (HFrEF) was evaluated on Clinical characteristics, comorbidities, and echocardiographic parameters. Patients with HFpEF were older (73.2 vs. 70.4 years; p<0.001) and had more frequent hypertension (85.4% vs. 71.5%) and atrial fibrillation (52% vs. 44.7%) compared to those with HFrEF.
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