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The aim is to explore methodologies for characterizing the gut virome and its implications for human health and disease.

February 6, 2026mSystemsOpen Access

Tools and approaches to study the human gut virome: from the bench to bioinformatics

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The aim is to explore methodologies for characterizing the gut virome and its implications for human health and disease.
Describes culture-dependent approaches to cultivate gut viruses.
Details culture-independent methods for virome analysis.
Outlines high-throughput screening techniques for examining viral-bacterial interactions.
Provides a workflow for identifying uncultivated viral genomes from fecal metagenomes.
Characterization of the gut virome presents unique challenges due to its diversity.
Opportunities to integrate wet- and dry-lab techniques are identified.
High-throughput screens can enhance understanding of viral-bacterial dynamics.

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Mini-review reports various methodologies to examine the gut virome, highlighting implications for human health.

Hallowell et al. (2026) studied this question.

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