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February 6, 2026European Heart Journal0 citations

Impact of Real World Evidence on Sacubitril/Valsartan Adoption

Quantifying the impact of real-world evidence: the sacubitril/valsartan experience

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Authors

AEA J EpsteinMPM H PerskySRS S Rathore

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Overview

Analysis of real-world evidence publications shows increased sales of sacubitril/valsartan over time, suggesting implications for therapy adoption.

Key Points

  • This research aims to quantify how the publication of real-world evidence affects the sales of sacubitril/valsartan after its launch.
  • Conducted a PubMed search for studies related to sacubitril/valsartan and heart failure from 2015 to 2023.
  • Classified studies as RWE if they included patient endpoints derived from real-world experiences.
  • Analyzed the relationship between RWE publications and quarterly sales using linear regression.
  • Out of 888 identified studies, 333 were deemed RWE-related.
  • Each additional RWE publication was associated with an increase in sales of sacubitril/valsartan, peaking after two quarters.
  • An additional RWE publication resulted in an estimated mean sales increase of $2.6M from one quarter to the next.

Cite This Study

Epstein et al. (2025) studied this question.

synapsesocial.com/papers/6985859b8f7c464f230091fchttps://doi.org/10.1093/eurheartj/ehaf784.1138
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