Key result
Global early-onset ASCVD prevalence increased slightly since 1990, with heavier burden in men and low-SDI countries.
Why the study?
Early-onset atherosclerotic cardiovascular diseases impose a significant burden on individuals, families, and society, but global, regional, and national burden trends remained to be evaluated.
Population
Global population aged 15-55 years with early-onset ASCVD from the GBD 2021 study
Comparison
Temporal trends from 1990 to 2021 across countries and regions
Design
Population-based study using GBD 2021 data
Authors
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Slight global rise in early-onset ASCVD prevalence, concentrated in low-SDI regions and men, warrants targeted risk-factor monitoring; leaves open causal drivers and prevention efficacy.
Observational
Yes
Absolute Event Rate: 1551.5% vs 1547.3%
The global burden of early-onset ASCVD remains high and is increasing, particularly in men and lower sociodemographic index regions, driven by modifiable risk factors like dietary risks, high LDL, and high systolic blood pressure.
Du et al. (2025) conducted an observational in Early-onset atherosclerotic cardiovascular diseases (ASCVD). Time period (2021) vs. 1990 was evaluated on Age-standardized prevalence rate (ASPR) per 100,000 persons. The global age-standardized prevalence rate of early-onset ASCVD increased slightly from 1547.3 per 100,000 persons in 1990 to 1551.5 per 100,000 persons in 2021.
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