Bisalbuminemia associated with monoclonal gammopathy in a patient with lymphoma: A Case Report

Bisalbuminemia is a rare electrophoretic abnormality characterized by two distinct albumin fractions on serum protein electrophoresis [4,5]. Although it is most often hereditary, acquired forms may occur in various pathological conditions. Its association with lymphoproliferative disorders and monoclonal gammopathy is uncommon and poorly documented [7]. We report the case of a 32-year-old man diagnosed with lymphoma, whose serum protein electrophoresis revealed marked bisalbuminemia associated with an IgG kappa monoclonal spike. Immunotyping confirmed the monoclonal nature of the gamma peak [2,7]. Radiological investigations identified multiple lymphadenopathies and secondary neurological involvement. This case highlights the analytical significance of bisalbuminemia in high-resolution electrophoresis and discusses its possible pathophysiological mechanisms in lymphoma [4,6]. Awareness of this rare electrophoretic pattern is essential to avoid misinterpretation and ensure accurate detection of clinically significant monoclonal components [2,6].