Key result
Failure to improve KCCQ score by ≥5 at 2 months post-discharge was associated with significantly higher odds of readmission (OR 5.1; 95% CI 2.4-11.0) and mortality (OR 3.7; 95% CI 1.3-10.2).
Why the study?
Identifying patients with CHF at highest post-discharge risk remains challenging, prompting evaluation of whether failure to improve KCCQ score 2 months post-discharge predicts death or readmission.
Does a failure to improve KCCQ score by ≥5 at 2 months after discharge predict death or readmission in patients with CHF?
Cohort (n=221)
Does a failure to improve KCCQ score by ≥5 at 2 months after discharge predict death or readmission in patients with CHF?
Failure to achieve a clinically meaningful improvement in quality of life (KCCQ score increase <5) 2 months after an unplanned heart failure hospitalization identifies patients at very high risk for readmission or death.
May flag high-risk HF patients for closer post-discharge monitoring; hypothesis-generating for trials targeting KCCQ improvement.
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McGinlay et al. (2025) conducted a cohort in Congestive Heart Failure (CHF) (n=221). Failure to improve KCCQ score by ≥5 at 60 days (Non-responder) vs. Improvement in KCCQ score by ≥5 (Responder) was evaluated on All-cause readmission (OR 5.1, 95% CI 2.4 - 11.0, p=<0.001). Failure to improve KCCQ score by ≥5 at 2 months post-discharge was associated with significantly higher odds of readmission (OR 5.1; 95% CI 2.4-11.0) and mortality (OR 3.7; 95% CI 1.3-10.2).
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