Key result
New-onset VAs after PCI are linked to ~11-fold greater syncope risk and increased AHF readmissions.
Why the study?
Ventricular arrhythmias are a common cause of death in coronary heart disease, but the impact of new-onset ventricular arrhythmias after PCI on prognosis remains unclear.
Does new-onset ventricular arrhythmia after PCI increase the risk of cardiac death or other adverse events in patients undergoing PCI?
Cohort (n=9,431)
Does new-onset ventricular arrhythmia after PCI increase the risk of cardiac death or other adverse events in patients undergoing PCI?
New-onset ventricular arrhythmias occurring >48 hours post-PCI are not independently associated with mortality but significantly increase the risk of syncope and heart failure readmission.
Background Ventricular arrhythmias (VAs) are a common cause of death in patients with coronary heart disease (CHD); however, the impact of new-onset VAs after percutaneous coronary intervention (PCI) on prognosis remains unclear. The aim of this study was to investigate the risk factors for the occurrence of VAs after PCI and their effects on prognosis. Methods Patients undergoing PCI enrolled from January 2013 to December 2013. New-Onset VAs are defined as those occurring after 48 hours post- PCI. The primary endpoint of this study is cardiac death. All-cause death, acute heart failure (AHF)-related readmission, and syncope were considered secondary endpoints. Results A total of 9,431 patients were included. Among them, 336 (3.6%) patients developed new-onset VAs during follow-up after discharge. During the 6-year follow-up period, a total of 368 patients died, 117 patients hospitalized due to AHF, 76 patients experienced syncope. Multivariate Cox analysis indicates that new-onset VAs was not independently associated with all-cause mortality or cardiac mortality (Figure 1). However, the new-onset VAs group had significantly higher rates of syncope (6.5% vs. 0.6%, p < 0.001) and AHF-related readmission (4.2% vs. 1.1%, p < 0.001) (Figure 2). In addition, the new-onset VAs was identified as an independent risk factor for both syncope and AHF-related readmission. Older age, PCI history, and coronary artery bypass grafting history were identified as independent risk factors for new-onset VAs during the follow-up period. Conclusions Although new-onset VAs after PCI may not be fatal, it is associated with an increased risk of syncope and AHF-related readmission.
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Su et al. (2025) conducted a cohort in Coronary heart disease undergoing percutaneous coronary intervention (n=9,431). New-onset ventricular arrhythmias vs. No new-onset ventricular arrhythmias was evaluated on Cardiac death. New-onset ventricular arrhythmias after PCI were not associated with cardiac mortality, but were linked to higher rates of syncope (6.5% vs. 0.6%) and AHF-related readmission (4.2% vs. 1.1%).
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