What does this research mean for the field?

Left bundle branch area pacing improved LV synchronicity and function at 6 months compared to right ventricular pacing in patients with atrioventricular block (all p<0.05). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

Evaluate the effects of left bundle branch area pacing on left ventricular synchrony and function compared to right ventricular pacing in atrioventricular block.

February 6, 2026European Heart Journal

Preservation of synchronicity and function by left bundle branch area pacing for atrioventricular block: a randomized controlled trial

Q: What are the key findings of this study?

Left bundle branch area pacing showed superior left ventricular synchronicity, global longitudinal strain, and myocardial work compared to right septal ventricular pacing at 6 months (all p<0.05).

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Atrioventricular block (AVB) (n=80). Intervention: Left bundle branch area pacing (LBBAP) vs. Right septal ventricular pacing (RVSP). Primary outcome: Left ventricular systolic synchrony and function (p=<0.05).

Q: What question did this study set out to answer?

Evaluate the effects of left bundle branch area pacing on left ventricular synchrony and function compared to right ventricular pacing in atrioventricular block.

View Full Paper

Ask AI

Bookmark

Key result

LBBAP improves LV synchronicity and function vs RVP at 6 months in AV block.

P<0.05
n=80

Why the study?

Evidence from randomized controlled trials was lacking regarding the clinical superiority of LBBAP over right ventricular pacing for preserving LV synchrony and function in atrioventricular block.

Does left bundle branch area pacing improve left ventricular systolic synchrony and function in patients with atrioventricular block compared to right septal ventricular pacing?

Key Points

Evaluate the effects of left bundle branch area pacing on left ventricular synchrony and function compared to right ventricular pacing in atrioventricular block.
Randomized controlled trial with 80 patients assigned to LBBAP or RVSP.
Measured QRS duration, peak strain dispersion percentage, global longitudinal strain, and myocardial work.
Follow-up assessments conducted at 3 days and 6 months post-implantation.
LBBAP group showed significant recovery in left ventricular synchrony and function at 6 months follow-up.
LBBAP demonstrated superiority in QRS duration, peak strain dispersion percentage, global longitudinal strain, and myocardial work compared to RVSP (all p<0.05).
Both groups displayed acute improvements in left ventricular function at 3 days, but only LBBAP maintained these improvements at 6 months.

Study Design

Type

RCT (n=80)

Structured PICO

Does left bundle branch area pacing improve left ventricular systolic synchrony and function in patients with atrioventricular block compared to right septal ventricular pacing?

Population

80 patients (mean age 63 years, 50% female) with atrioventricular block, followed for 6 months.

Intervention

Left bundle branch area pacing (LBBAP)

Comparator

Right septal ventricular pacing (RVSP)

Outcome

Left ventricular systolic synchrony and function (assessed via QRS duration, peak strain dispersion percentage, global longitudinal strain, and myocardial work) at 6-month follow-upsurrogate

Main Result

p-value: p=<0.05

Left bundle branch area pacing preserves left ventricular synchrony and systolic function significantly better than right ventricular septal pacing at 6 months in patients with atrioventricular block.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports LBBAP over RV pacing in AV block to preserve LV function; confirms consensus with RCT evidence.

Cite This Study

Liu et al. (2025) conducted an RCT in Atrioventricular block (AVB) (n=80). Left bundle branch area pacing (LBBAP) vs. Right septal ventricular pacing (RVSP) was evaluated on Left ventricular systolic synchrony and function (p=<0.05). Left bundle branch area pacing showed superior left ventricular synchronicity, global longitudinal strain, and myocardial work compared to right septal ventricular pacing at 6 months (all p<0.05).

synapsesocial.com/papers/698586ad8f7c464f2300a6ff https://doi.org/10.1093/eurheartj/ehaf784.650

View Full Paper

Ask AI

Bookmark

Preservation of synchronicity and function by left bundle branch area pacing for atrioventricular block: a randomized controlled trial

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Preservation of synchronicity and function by left bundle branch area pacing for atrioventricular block: a randomized controlled trial

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider