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November 29, 2022The American Journal of CardiologyOpen Access

At 4 weeks, LBBAP significantly improved the systolic dyssynchrony index (2.5 ± 0.3 vs 5.9 ± 0.9 vs 7.7 ± 1.2, p = 0.001) and paced QRS duration (115 ± 26 vs 134 ± 28 vs 157 ± 29 ms, p = 0.012) compared with RVSP or RVAP.

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Why the study?

Does left bundle branch area pacing improve ventricular mechanical synchronization compared to right ventricular pacing in patients with normal LVEF?

Population

90 patients with normal left ventricular ejection fraction

Comparison

LBBAP vs RVSP vs RVAP

Follow-up

4 weeks

Authors

YMYingchen MeiRHRui HanLCLiting Cheng

Discussion

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Overview

LBBAP prolongs procedure and fluoroscopy times; leaves open net benefit versus septal or apical pacing in preserved LVEF.

Structured PICO

Does left bundle branch area pacing improve ventricular mechanical synchronization compared to right ventricular pacing in patients with normal LVEF?

P
Population
90 patients with normal left ventricular ejection fraction requiring pacemaker implantation
I
Intervention
Left bundle branch area pacing (LBBAP)
C
Comparator
Right ventricular septal pacing (RVSP) or right ventricular apical pacing (RVAP)
O
Outcome
Ventricular mechanical synchronization and cardiac function (assessed by systolic dyssynchrony index, global longitudinal strain, and brain natriuretic peptide levels) at 4 weeks of follow-upsurrogate

Left bundle branch area pacing provides a more physiological ventricular activation pattern and better mechanical synchronization than traditional right ventricular pacing in patients with normal ejection fraction.

Cite This Study

Mei et al. (2022) studied this question.

synapsesocial.com/papers/6a8d086c82ee45910f2fdf87https://doi.org/10.1016/j.amjcard.2022.10.012
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