A retrospective cohort study finds that lower serum calcium is linked to higher mortality in osteoarthritis patients, suggesting clinical implications.
Our primary analysis supports an inverse linear association between serum calcium and mortality in OA patients. Although exploratory analyses revealed potential non-linear patterns visually, these were not statistically confirmed. Therefore, the overall relationship is best characterized as linear within the observed range, with lower serum calcium associated with higher mortality risk. Therefore, these findings highlight a potential optimal range for serum calcium but require verification in future studies designed to confirm nonlinearity and assess the clinical utility of calcium management.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: