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Synapse
February 8, 2026Open Access

Microcirculatory Resistance After Primary Percutaneous Coronary Intervention Predicts Residual Myocardial Damage and Scar Formation

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Why the study?

Coronary microvascular dysfunction is associated with adverse cardiovascular events after acute myocardial infarction, prompting evaluation of angiography-derived index of microcirculatory resistance (angio-IMR) for predicting myocardial damage.

Does post-PCI angio-IMR predict myocardial infarct size and microvascular obstruction in patients with STEMI?

Population

Patients with ST-segment-elevation myocardial infarction undergoing primary PCI

Comparison

Angiography-derived index of microcirculatory resistance (angio-IMR)

Key result

Post-primary PCI angio-IMR independently predicts myocardial infarct size and microvascular obstruction in STEMI patients.

Authors

ACAlessandro CandrevaAGAlexander GotschyJSJulia Stehli

Discussion

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Overview

May aid post-PCI risk stratification in STEMI; extends prior microvascular data but leaves clinical adoption open.

Key Points

  • This study aims to assess the predictive capacity of the angiography-derived index of microcirculatory resistance (angio-IMR) on myocardial damage following PCI.
  • Evaluated patients with ST-segment-elevation myocardial infarction (STEMI) undergoing primary PCI.
  • Measured the angiography-derived index of microcirculatory resistance post-PCI.
  • Analyzed the relationship between angio-IMR and myocardial damage outcomes.
  • Post-PCI angio-IMR was identified as an independent predictor of myocardial infarct size.
  • Higher angio-IMR values correlated with greater microvascular obstruction.

Structured PICO

Does post-PCI angio-IMR predict myocardial infarct size and microvascular obstruction in patients with STEMI?

P
Population
Patients with ST-segment-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)
I
Intervention
Measurement of post-PCI angiography-derived index of microcirculatory resistance (angio-IMR)
O
Outcome
Myocardial infarct size and extent of microvascular obstruction (residual myocardial damage and scar formation)surrogate

Post-PCI angio-IMR serves as an independent predictor of infarct size and microvascular obstruction in STEMI patients, suggesting its utility in assessing residual myocardial damage.

Cite This Study

Candreva et al. (2025) studied this question. Post-primary PCI angio-IMR independently predicts myocardial infarct size and microvascular obstruction in STEMI patients.

synapsesocial.com/papers/698827570fc35cd7a88460e1https://doi.org/10.5167/uzh-290502
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship Between Post-Procedural Angiography-Derived Index of Microcirculatory Resistance and Periprocedural Myocardial Injury After Percutaneous Coronary Intervention2026
  2. 2Prognostic Value of Coronary Angiography–Derived Index of Microcirculatory Resistance in Non–ST-Segment Elevation Myocardial Infarction Patients2024 · 32 citations
  3. 3The Index of Microcirculatory Resistance after Primary Percutaneous Coronary Intervention Predicts Long-Term Clinical Outcomes in Patients with ST-Segment Elevation Myocardial Infarction2021 · 14 citations
  4. 4The Index of Microcirculatory Resistance Predicts Myocardial Infarction Related to Percutaneous Coronary Intervention2012 · 78 citations
  5. 5Periprocedural assessment of coronary microcirculatory function to predict clinical outcomes after elective PCI2025