This strategy demonstrates efficient coupling of radicals in unactivated alkenes, suggesting new synthetic routes.
Herein, we report a strategy for the methylalkylation of unactivated alkenes via synergistic photoredox/nickel catalysis. This mild transformation employs di-tert-butyl peroxide (DTBP) as a bifunctional reagent, which serves simultaneously as a hydrogen atom transfer (HAT) reagent and a source of methyl radical, thereby facilitating the coupling of malonate-derived radicals with alkenes. By integrating HAT with radical selectivity control, the method enables the formation of two C(sp³)-C(sp³) bonds in a single synthetic operation, offering a streamlined route to valuable three-dimensional scaffolds.
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Zhang et al. (2026) studied this question.
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