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Electrochemical Deuteration of Allylic Esters with Divergent Site-Selectivity | Synapse

February 8, 2026Organic Chemistry Frontiers0 citations

Electrochemical Deuteration of Allylic Esters with Divergent Site-Selectivity

XZXu Zhang KLKe Liu MWMohan Wang

Key Points

The aim is to develop a method for site-selective deuteration of allylic esters for pharmaceutical applications.
Utilized electrochemical techniques for deuteration
Targeted different sites on allylic esters
Applied divergent protocols for selective incorporation
Successfully demonstrated selective deuteration at various sites
Achieved different incorporation patterns in bioactive molecules
Highlighted the potential impact on pharmaceutical discovery

Abstract

Deuterium-labelling technology has emerged as a new promising direction for the pharmaceutical discovery. Developing a divergent protocol to incorporating deuterium into different sites of bioactive molecules is highly desirable, as...

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Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/698828770fc35cd7a8847ff1 https://doi.org/https://doi.org/10.1039/d5qo01759a

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