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February 8, 2026European Heart Journal

Systemic thrombolysis vs catheter-directed interventions for the treatment of high-risk pulmonary embolism. A comparative analysis of early outcomes and complications

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Authors

JSJ StepniewskiSSS Slawek-SzmytAAA Araszkiewicz

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Overview

This comparative analysis evaluates early outcomes and complications of systemic thrombolysis versus catheter-directed interventions in high-risk pulmonary embolism patients, suggesting favorable...

Key Points

  • The study evaluates early outcomes and complications between systemic thrombolysis and catheter-directed embolectomy in high-risk pulmonary embolism patients.
  • Evaluated medical records from registries of Pulmonary Embolism Response Teams (PERT) in cardiology centers.
  • Compared clinical profiles, treatment strategies, and outcomes including in-hospital mortality and major bleeding rates.
  • Analyzed outcomes after treatment with systemic thrombolysis and catheter-directed embolectomy.
  • Identified 111 high-risk pulmonary embolism patients.
  • In-hospital mortality was 6.9% for catheter-directed embolectomy compared to 45.8% for systemic thrombolysis (p<0.001).
  • Major bleeding occurred in 22.5% of patients treated with systemic thrombolysis versus 5.1% with catheter-directed embolectomy (p=0.03).

Cite This Study

Stepniewski et al. (2025) studied this question.

synapsesocial.com/papers/698828990fc35cd7a8848260https://doi.org/10.1093/eurheartj/ehaf784.2880
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catheter-Based Therapies Decrease Mortality in Patients With Intermediate and High-Risk Pulmonary Embolism: Evidence From Meta-Analysis of 65,589 Patients2022 · 36 citations
  2. 2Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis2023 · 23 citations
  3. 3Reperfusion therapies in patients with intermediate- and high-risk pulmonary embolism: insights from a multicenter registry2024 · 3 citations
  4. 4Outcomes of catheter-directed versus systemic thrombolysis for the treatment of pulmonary embolism: A real-world analysis of national administrative claims2020 · 36 citations
  5. 5Successful Catheter‐Directed Thrombolysis for a Patient With Intermediate‐High‐Risk Pulmonary Embolism: A Case Report2026