Key result
Catheter-directed thrombolysis for pulmonary embolism was associated with lower in-hospital mortality (6.5% vs 10.0%, p=0.02) and higher all-cause bleeding (15.9% vs 8.7%) than systemic thrombolysis.
Why the study?
Catheter-directed thrombolysis and systemic thrombolysis are used to treat intermediate/high-risk pulmonary embolism despite a lack of comparative safety and effectiveness data.
Does catheter-directed thrombolysis improve mortality and bleeding outcomes compared to systemic thrombolysis in patients with pulmonary embolism?
Population
1915 patients receiving CDT or ST among 100,744 patients hospitalized with PE
Comparison
Catheter-directed thrombolysis vs systemic thrombolysis
Design
Retrospective propensity score-matched administrative claims database study
Authors
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CDT was associated with lower mortality but higher bleeding than ST in PE; leaves open need for RCTs to guide selection.
Cohort (n=1,915)
Yes
Does catheter-directed thrombolysis improve mortality and bleeding outcomes compared to systemic thrombolysis in patients with pulmonary embolism?
Absolute Event Rate: 6.5% vs 10%
p-value: p=0.02
In a real-world cohort of patients with pulmonary embolism, catheter-directed thrombolysis was associated with lower in-hospital mortality but higher all-cause bleeding compared to systemic thrombolysis.
Geller et al. (2020) conducted a cohort in Pulmonary embolism (n=1,915). Catheter-directed thrombolysis vs. Systemic thrombolysis was evaluated on In-hospital mortality (p=0.02). Catheter-directed thrombolysis for pulmonary embolism was associated with lower in-hospital mortality (6.5% vs 10.0%, p=0.02) and higher all-cause bleeding (15.9% vs 8.7%) than systemic thrombolysis.
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