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February 8, 2026HaematologicaOpen Access

Fibrin-bound thrombin determines clot structure and blood thrombogenicity in normofibrinogenemia and dysfibrinogenemia

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Authors

SSSiyu SunSynapse (Netherlands)MRMark R. RoestVORtech (Netherlands)RURolf T. UrbanusUniversity Medical Center Utrecht

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Overview

Explores how fibrin-bound thrombin affects clot structure and thrombogenicity in fibrinogen disorders, suggesting new therapeutic options.

Key Points

  • This research aims to understand how thrombin interacts with fibrin to influence clot structure and thrombogenic potential in normal and abnormal fibrinogen cases.
  • Utilized immunological and genetic methods to study thrombin's role within fibrin clots.
  • Analyzed thrombin’s activity and stability through displacement and peptide mimics.
  • Evaluated thrombin capacity in patients with congenital dysfibrinogenemia and associated genetic mutations.
  • Fibrin-bound thrombin was found to be active and protected from inactivation by antithrombin-III.
  • Displacement of thrombin from fibrin decreased its activity significantly.
  • Patients with dysfibrinogenemia exhibited high thrombin activity and reduced complex formation with antithrombin-III.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/698828990fc35cd7a88483abhttps://doi.org/10.3324/haematol.2025.288585
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Also Consider

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  1. 1Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen2024 · 57 citations
  2. 2Identification of Critical Residues on Thrombin Mediating Its Interaction with Fibrin2001 · 30 citations
  3. 3FIBRINOGEN INTERACTION WITH PLATELET RECEPTORS*†1983 · 56 citations
  4. 4Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation2020 · 34 citations
  5. 5Fibrin as a thrombin sink: a factor retaining a thrombus in the stillness phase2026 · 2 citations