Key result
Hemodialysis linked to greater RVFWLS decline than peritoneal dialysis, raising mortality and heart failure risk ~318%.
Why the study?
End-stage renal disease patients face an increased risk of cardiovascular disease and cardiac impairment, motivating a comparison between peritoneal dialysis and hemodialysis regarding their effects on cardiac function and clinical outcomes.
Does peritoneal dialysis compared to hemodialysis preserve right ventricular function and improve clinical outcomes in patients with end-stage renal disease?
Population
96 end-stage renal disease patients undergoing renal replacement therapy
Comparison
Peritoneal dialysis vs hemodialysis
Design
Prospective cohort study
Authors
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HD-associated RVFWLS decline signals higher HF and mortality risk in ESRD; leaves open whether peritoneal dialysis better preserves RV function.
Does peritoneal dialysis compared to hemodialysis preserve right ventricular function and improve clinical outcomes in patients with end-stage renal disease?
In patients with end-stage renal disease, hemodialysis is associated with a progressive decline in right ventricular systolic function compared to peritoneal dialysis, and this decline strongly predicts heart failure hospitalization and mortality.
Fu et al. (2025) studied this question. Hemodialysis was linked to a decline in right ventricular function (RVFWLS) compared to peritoneal dialysis, with decreased RVFWLS raising mortality and heart failure risk (HR 4.181).
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