Key result
Endometriosis is linked to a ~15% higher risk of MACE.
Why the study?
Does endometriosis increase the risk of adverse cardiovascular outcomes in women compared to those without the condition?
Meta-Analysis (n=1,407,875)
Does endometriosis increase the risk of adverse cardiovascular outcomes in women compared to those without the condition?
Hazard Ratio: 1.15 (95% CI 1.13–1.19)
p-value: p=<0.00001
Endometriosis is associated with a significantly increased risk of ischemic heart disease, cerebrovascular disease, arrhythmias, and major adverse cardiovascular events, highlighting the need for cardiovascular risk assessment in this population.
Background The association between endometriosis and cardiovascular disease remains poorly understood. Emerging evidence suggests a potential link between endometriosis and increased cardiovascular risk, necessitating a comprehensive evaluation. Purpose This study aimed to conduct a systematic review and meta-analysis to assess the risk of adverse cardiovascular outcomes in women with endometriosis compared to those without the condition. Methods A comprehensive search of online databases was performed up to November 2024 to identify studies comparing adverse cardiovascular outcomes in women with and without endometriosis. A random-effects model was employed for the meta-analysis to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Results The meta-analysis included seven studies encompassing a total of 1,407,875 participants. Women with endometriosis demonstrated a significantly increased risk of cerebrovascular disease (HR: 1.19, 95% CI: 1.13–1.24, p < 0.00001) and ischemic heart disease (HR: 1.35, 95% CI: 1.32–1.39, p < 0.00001). Additionally, the risk of major adverse cardiovascular events (HR: 1.15, 95% CI: 1.13–1.19, p < 0.00001) and arrhythmias (HR: 1.21, 95% CI: 1.17–1.25, p < 0.00001) was significantly elevated. However, no significant associations were observed for heart failure or all-cause mortality. Conclusion This meta-analysis indicates that women with endometriosis are at heightened risk for several cardiovascular conditions. These findings underscore the need for robust prospective studies to validate these associations and to explore underlying mechanisms.
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Saad et al. (2025) conducted a meta-analysis in Endometriosis (n=1,407,875). Endometriosis vs. Women without endometriosis was evaluated on Major adverse cardiovascular events (HR 1.15, 95% CI 1.13-1.19, p=<0.00001). Endometriosis was associated with a significantly increased risk of major adverse cardiovascular events compared to women without the condition (HR 1.15; 95% CI 1.13-1.19; p<0.00001).
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