What is the clinical evidence from this study?

Study design: Observational. Population: Cardiac arrest. Intervention: Acidemia (pH ≤7.2) vs. pH >7.2. Primary outcome: 30-day and in-hospital mortality (HR 0.14, p=<0.0001).

What question did this study set out to answer?

This research aims to evaluate the independent predictive value of pH levels along with lactate in cardiac arrest outcomes.

February 8, 2026European Heart Journal

Acidemia is associated with a higher mortality independently of lactate levels in cardiac arrest patients

Q: What are the key findings of this study?

Initial pH levels ≤7.2 were independently associated with higher mortality in cardiac arrest patients, with a hazard ratio of 0.14 per pH unit (p<0.0001).

Q: What question did this study set out to answer?

This research aims to evaluate the independent predictive value of pH levels along with lactate in cardiac arrest outcomes.

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Key result

Initial pH ≤7.2 is linked to an ~86% increase in cardiac arrest mortality per unit decrease.

HR 0.14
P<0.0001

Why the study?

Does initial pH level predict 30-day mortality independently of lactate levels in cardiac arrest patients following CPR?

Population

Non-traumatic cardiac arrest patients following cardiopulmonary resuscitation admitted to a high-volume…

Design

Cohort

Follow-up

30 days

Authors

DDDragos Andrei DuseDüsseldorf University Hospital AGAndreea GaneaUniversity of Cologne PHP HornDüsseldorf University Hospital

Discussion

Member takes

Implication

Initial pH ≤7.2 is an independent predictor of 30-day mortality in cardiac arrest survivors, adding prognostic value to serum lactate levels.

Key Points

This research aims to evaluate the independent predictive value of pH levels along with lactate in cardiac arrest outcomes.
Retrospective analysis of non-traumatic cardiac arrest patients in a high-volume center.
Assessment of initial pH and lactate levels using receiver operating characteristic (ROC) curves.
Stratification of patients based on the Youden Index for lactate and a threshold of 7.2 for pH.
Utilization of Cox regression analyses to establish an association between pH, lactate, and mortality.
Initial pH and lactate levels are accurate in predicting in-hospital mortality (AUC of 0.83 for lactate, 0.75 for pH).
Patients with pH levels ≤7.2 show significantly higher mortality across lactate groups.
Hazard ratios for pH range from 0.1 to 0.3 after adjustments, indicating strong predictive value.
No significant correlation found between initial pH levels and neurological outcomes in patients.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Does initial pH level predict 30-day mortality independently of lactate levels in cardiac arrest patients following CPR?

Population

Non-traumatic cardiac arrest patients following cardiopulmonary resuscitation, including a validation cohort of over 2000 patients from multiple ICUs.

Exposure

Initial pH and lactate level assessment

Outcome

30-day mortality / in-hospital mortalityhard clinical

Main Result

Hazard Ratio: 0.14

p-value: p=<0.0001

Initial pH ≤7.2 is an independent predictor of 30-day mortality in cardiac arrest survivors, adding prognostic value to serum lactate levels.

Cite This Study

Duse et al. (2025) conducted an observational in Cardiac arrest. Acidemia (pH ≤7.2) vs. pH >7.2 was evaluated on 30-day and in-hospital mortality (HR 0.14, p=<0.0001). Initial pH levels ≤7.2 were independently associated with higher mortality in cardiac arrest patients, with a hazard ratio of 0.14 per pH unit (p<0.0001).

synapsesocial.com/papers/698828cb0fc35cd7a884892a https://doi.org/10.1093/eurheartj/ehaf784.2187

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Implication

Initial pH ≤7.2 is an independent predictor of 30-day mortality in cardiac arrest survivors, adding prognostic value to serum lactate levels.

Acidemia is associated with a higher mortality independently of lactate levels in cardiac arrest patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Acidemia is associated with a higher mortality independently of lactate levels in cardiac arrest patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider