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February 8, 2026Journal of International Medical ResearchOpen Access

Association between Helicobacter pylori infection and insulin resistance: Data from the US and Chinese cohorts

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Authors

SHShali HaoThe First People's Hospital of ShundeYZYoubing ZhangThe First People's Hospital of ShundeLLLingxiao LiThe First People's Hospital of Shunde

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Implication

Cross-sectional analysis investigates insulin resistance in US and Chinese cohorts, suggesting no consistent link to infection.

Key Points

  • The study aims to explore the relationship between Helicobacter pylori infection and insulin resistance in diverse populations.
  • Conducted a cross-sectional analysis using two cohorts: US National Health and Nutrition Examination Survey and Southern China inpatients.
  • Determined Helicobacter pylori infection via serum antibodies, 13 C-urea breath test, or rapid urease test.
  • Assessed insulin resistance using triglyceride-glucose index or homeostasis model assessment of insulin resistance.
  • Applied multivariate linear regression models for analysis.
  • In the US cohort, Helicobacter pylori positivity was initially linked to a higher triglyceride-glucose index, but lost significance after adjustments.
  • No significant association was found in the US cohort's homeostasis model assessment of insulin resistance index.
  • In the Southern China cohort, no significant relationship existed between Helicobacter pylori status and triglyceride-glucose index.

Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/6988291e0fc35cd7a88493a8https://doi.org/10.1177/03000605261416741
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic review with meta‐analysis: the worldwide prevalence of Helicobacter pylori infection2018 · 762 citations
  2. 2Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease2023 · 21 citations
  3. 3Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation2010 · 128 citations