Association of Helicobacter pylori infection with elevated low-density lipoprotein cholesterol and fasting glucose: a large-scale analysis of 83,054 participants in central China
Retrospective analysis shows H. pylori infection correlates with elevated LDL-C and fasting glucose in a large Chinese cohort, suggesting broader metabolic implications.
Key Points
This study aimed to quantify the association between H. pylori infection and metabolic markers LDL-C and fasting glucose.
Retrospective cross-sectional analysis of 83,054 participants
H. pylori status determined using 13C Urea Breath Test
Multivariable logistic regression adjusted for age, gender, BMI, and biochemical profile.
H. pylori prevalence was 26.55% overall and 28.80% in the 50–54 age group.
Elevated LDL-C was independently associated with H. pylori (aOR = 1.34, 95% CI: 1.27–1.41, P < .001).
Fasting glucose was also significantly correlated with H. pylori positivity (aOR = 1.04, 95% CI: 1.03–1.05, P < .001).