Targeted PET imaging improves with a new dimeric FAP ligand in cancer, suggesting enhanced diagnostic capabilities.
hmFAP₂ markedly enhances FAP-targeting efficiency, providing higher binding affinity, improved tumor uptake, and reduced nonspecific distribution compared with its monomeric counterpart. The favorable imaging properties of hmFAP₂ position it as a promising candidate for translation into clinical PET imaging and as a potential scaffold for developing FAP-targeted theranostic agents.
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Li et al. (2026) studied this question.
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