Polynucleotides purified through High Purification Technology (PN HPT), combined with hyaluronic acid (HA), represent a novel injectable strategy to improve skin quality in aesthetic medicine. This real-world data collection aimed to evaluate the safety and performance of PN HPT-based treatments across multiple facial and body areas. Data were collected through a post-market clinical follow-up survey, analysing 218 questionnaires completed after 654 intradermal infiltrations performed on the face (e.g., forehead, perioral lines, crow’s feet), neck, hands, and décolleté. Aesthetic outcomes were assessed using clinician- and patient-reported Global Aesthetic Improvement Scale and Global Clinical Improvement Scale scores. Safety and satisfaction were evaluated through adverse event reporting and a patient-completed Likert scale. Across all treated areas, consistent improvement was observed. For the face, 39% of cases achieved “marked improvement” or “excellent result” on the GCI-S, with 48% rated as “much improved” or “very much improved” on the GAIS. Similar outcomes were reported for the neck (41% and 57%), hands (31% and 41%), and décolleté (43% and 55%). Patient satisfaction was high, with over 90% expressing general satisfaction and willingness to repeat the treatment. No serious or unexpected adverse events occurred. These findings suggest that PN HPT and HA injectables may offer a high level of patient satisfaction, observable improvements in skin quality, and a favorable safety profile in the modern aesthetic practice.
Savoia et al. (2026) studied this question.