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June 11, 2026Journal of Cosmetic DermatologyOpen Access

Hybrid Calcium Hydroxylapatite–Polynucleotide Skin Booster A Retrospective Cohort Study

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Authors

ALAndrea LazzarottoSGStefania GuidaJKJonathan Kadouch

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Overview

Retrospective cohort analysis evaluates skin quality improvement from a CaHA–PN booster protocol in a real-world setting, suggesting promising safety and effectiveness.

Key Points

  • The study aims to assess the effectiveness and safety of a hybrid calcium hydroxylapatite–polynucleotide skin booster after six months.
  • Conducted a single-center, retrospective observational cohort analysis.
  • Included 36 consecutive patients treated with a fixed-dose hybrid protocol.
  • Graded facial skin quality and secondary outcomes using validated scales at baseline and 6 months.
  • Mean skin quality score improved from 2.7 ± 0.8 to 1.5 ± 0.6 (44.4% improvement; p < 0.001).
  • Cheek wrinkle severity improved from 2.4 ± 0.9 to 1.4 ± 0.5 (41.7% improvement; p < 0.001).
  • 86.1% reported high radiance (Likert ≥ 4), and 94.4% would recommend the treatment.

Cite This Study

Lazzarotto et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52d980c8f91e7f39ebe3https://doi.org/10.1111/jocd.70897
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-World Evaluation of an Injectable Treatment Containing Polynucleotides Purified with High Purification Technology (PN HPT) and Hyaluronic Acid for Skin Quality Improvement in Facial and Body Areas2026 · 2 citations
  2. 2An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy2026
  3. 3Toward a Personalized Protocol Based on Skin Atrophic and Hypertrophic Photoaging Type With Injectable <scp>CaHA</scp>2026
  4. 4Nucleotide‐Based Skin Boosters in Aesthetic Dermatology: A Scoping Review of Their Potential Role2026
  5. 5Exploratory Evaluation of a Hyper-Diluted Calcium Hydroxyapatite–Hyaluronic Acid Combination for Facial Rejuvenation: A Pilot Study2025 · 3 citations