What does this research mean for the field?

Personalized injectable Calcium Hydroxylapatite (CaHA) protocols tailored to atrophic and hypertrophic photoaging phenotypes significantly improve facial rejuvenation outcomes and yield high patient satisfaction. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To evaluate the efficacy and safety of personalized CaHA protocols for atrophic and hypertrophic photoaging types.

June 10, 2026Journal of Cosmetic DermatologyOpen Access

Toward a Personalized Protocol Based on Skin Atrophic and Hypertrophic Photoaging Type With Injectable CaHA

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To evaluate the efficacy and safety of personalized CaHA protocols for atrophic and hypertrophic photoaging types.
Retrospective assessment of CaHA treatments in 157 patients with a mean age of 62 years.
Evaluated efficacy using severity scales and GAIS at 6 months post-treatment.
Techniques included pure (30%) and hyperdiluted (1:2) CaHA, tailored to photoaging phenotype.
All severity scores significantly improved from 16.4 ± 4.2 to 7.0 ± 2.2 (p < 0.001).
HP patients showed greater improvement in specific facial areas (p = 0.028) with combined protocols than pure CaHA for AP patients (p < 0.001).
94% of patients reported high satisfaction on the GAIS, with no major adverse events.

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Implication

Retrospective study evaluates personalized CaHA treatments in photoaging types, showing significant clinical improvements.

Cite This Study

Guida et al. (2026) studied this question.

synapsesocial.com/papers/6a2900886f82f25be989d06b https://doi.org/10.1111/jocd.70979

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Toward a Personalized Protocol Based on Skin Atrophic and Hypertrophic Photoaging Type With Injectable CaHA

Key Points

Discussion

Implication

Cite This Study

Toward a Personalized Protocol Based on Skin Atrophic and Hypertrophic Photoaging Type With Injectable CaHA

Key Points

Discussion

Implication

Cite This Study

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